Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV- 2: An In Silico Approach

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes COVID-19 which responsible for illness infection in humans. The was first identified China 2019 and later spread to other countries worldwide. This study aims identify bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanisms against two SARS-CoV-2 proteases through silico approach. three-dimensional structure of various database examined. Furthermore, all target were analyzed drug, activity prediction, virtual screening, molecular interactions, threedimensional visualization. It aimed determine potential can serve agents fight SARS-CoV-2. Results showed have prospective provide contradict inhibitory mechanisms. In summary, binding results low energy expected ability induce any protein reaction. Therefore, it allows act infection. Key words: Antiviral agent, COVID-19, Garcinia L., approach,